- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
Leptin Level in Newly Diagnosed Iraqi Acromegaly Patients | ||
| Al-Mustansiriyah Journal for Pharmaceutical Sciences | ||
| Article 1, Volume 17, Issue 1, 2017, Pages 170-175 | ||
| Authors | ||
| Thair Tahir; | ||
| Abstract | ||
| Acromegaly is a serious endocrine disease resulting from an increase of growth hormone in the blood. Excessive growth hormone secretion may be caused by an adenoma of the pituitary. This study was designed to assess the effect of serum leptin concentration on acromegaly patients with both gender and its relation with some biochemical analysis. The study conducted 96 subjects (48 acromegaly patients and 48 controls) aged between (30-70) years who were attending the National Diabetic Center/ Al-Mustansirya University and Al-Yarmuk Teaching Hospital. Fasting blood sugar, lipid profile, growth hormone, insulin like growth factor-1, and serum leptin concentrations were measured for each individual. The results explained a significant increased in body mass index, triacylglycerol and low density lipoprotein cholesterol, (P<0.05) in acromegaly patients when compared with control group. Fasting blood sugar, serum growth hormone and serum insulin like growth factor-1 concentrations explained a highly significant increased, (P<0.01). While serum leptin concentration was significantly decreased. Fasting blood sugar, triacylglycerol, low density lipoprotein, serum growth hormone, serum insulin like growth factor-1, and serum leptin concentrations showed a significant increased in female patients when compared with male acromegaly patients, (P<0.05). This study showed that higher serum leptin levels with higher concentrations of triacylglycerol and low density lipoprotein cholesterol might play a vital function in the progress of acromegaly disease. Also, high serum leptin levels observed in female acromegaly patients when compared with male acromegaly patients, the present study suggested the role of leptin hormone as one of the biomarkers affecting in acromegaly patients.. | ||
| Keywords | ||
| Acromegaly; Growth hormone; insulin like growth factor; leptin; Lipid profile | ||
|
Statistics Article View: 151 PDF Download: 24 |
||