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Anew spectrophotometric method for determination of Famotidine drug | ||
| karbala journal of pharmaceutical sciences | ||
| Article 1, Volume 7, Issue 11, 2016, Pages 15-25 PDF (0 K) | ||
| Authors | ||
| Abdulbari Alhelfi; Rajwan Abd Aljabar | ||
| Abstract | ||
| Anew and simple sensitive reproducible spectrophotometric method was used for determination of famotidine drug(FA) in bulk sample and pharmaceutical formulation . The determination depend on formed the prussian blue by reacting the drug with iron(III) chloride to form iron(II) which reacts with potassium hexacyanoferrate(III). The product measurable spectrophotometrically at 744 nm. Regression analysis of Beers plot good correlation in the concentration range (1.00-6.00) μg.ml-1 No interference was observed from the usually existing additive in the pharmaceutical formulation and the applicability of the method was examined by analyzing tablets containing (FA). The correlation coefficient of 0.9982, a relative standard deviation (RSD%)of (2.07%) and the detection limit was (3.50×10-5) μg.ml-1and the sandell sensitivity was (1.70×10⁻⁴ μg.cm). Recoveries were (98.25-100.5 )% . | ||
| Keywords | ||
| Famotidine; spectrophotometric | ||
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