Salivary and Serum Oxidant/Antioxidant Level in Behçet’s Disease Patients

H. Mohammad, Noor

	Salivary and Serum Oxidant/Antioxidant Level in Behçet’s Disease Patients
Journal of Oral and Dental Research
Article 1, Volume 4, Issue 2, 2017, Pages 149-157
Author
Noor H. Mohammad
Abstract
Background Behçet’s disease (BD) is a multi-systemic inﬂammatory disorder characterized by recurrent oral and genital ulceration. Free oxygen radicals may have a role in the pathogenesis of BD and can relate to the existence of the disease. Objectives This study had been designed to assess salivary and serum lipid per-oxidation as malondialdehyde (MDA) and status of antioxidant as total glutathione (GSH) in patients with BD in comparison with healthy subjects to detect the possible involvement of oxidative stress in BD. Materials and methods This is a case–control study, salivary and serum samples were taken from ffty BD patients with an age range 20 to 56 years with mean age 35.3 ± 7.6 years and ffty healthy control subjects with age range 16 to 58 years and mean age 34.8± 9.1 years. All were analyzed for MDA and GSH spectrophotometrically. Data was analyzed using descriptive statistics, t-test, P (ANOVA) test, Chi-square (2X) test, Pearson correlation and Receiver Operating Characteristic statistical analyses. Results The study showed that salivary and serum MDA level was higher in BD patients than in healthy subjects (P<0.05 and P<0.001 respectively). The levels of saliva and serum total GSH were signifcantly lower in BD patients than in healthy subjects. (P <0.001). Conclusion The results of this study revealed that BD patients were subjected to oxidative stress damage and saliva could be used as pain-free alternatively to serum in determining oxidative stress in Behçet’s disease.
Keywords
Beh; MDA; GSH; saliva; Serum

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