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Evaluation of CD14 expression in Helicobacter pylori positive and Helicobacter pylori negative gastritis | ||
| Iraqi Journal of Science | ||
| Article 1, Volume 58, Issue 4, 2018, Pages 2070-2075 | ||
| Author | ||
| Manar Mustafa Ibraheem | ||
| Abstract | ||
| Monocytes are considered a key mediator of inflammatory cytokine secretions during inflammation. This study evaluates CD 14 expression in gastritis tissue biopsies of H. pylori and none H. pylori gastritis. This cross-sectional study involved 60 gastritis patients that have been classified into H. pylori positive (n=30) and H. pylori negative (n=30). Formalin fixed paraffin embedded tissue blocks were sectioned and immune-peroxidase staining with anti-CD14, then compared between study groups and clinical parameters. The results showed a marked difference in the percentage of expression in mild and severe intensity of inflammation sub-groups, the results showed a higher percentage of CD14 immunoreactivity (18.29±5.84 vs. 10.2±3.89, p=0.005) and (42.84±19.43 vs. 32.98±9.83, p=0.007) respectively. In conclusion, the percentage of CD14 immunoreactivity may closely related to the inflammatory gastritis induced by H. pylori bacterium. | ||
| Keywords | ||
| Monocyte; pylori and gastritis | ||
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