Reducing the Negative Effects of Cadmium by Using Vitamin E, as an Antioxidant

Abd El Fattah, Soheir; Al Kadir Kareem Rhumaid, Abd

	Reducing the Negative Effects of Cadmium by Using Vitamin E, as an Antioxidant
Diyala Journal For Pure Science
Article 1, Volume 14, Issue 1, 2018, Pages 43-57
Authors
Soheir Abd El Fattah; Abd Al kadir Kareem Rhumaid
Abstract
This study was done by using 200 Swiss mice, which had been divided into two main groups, each group contains (40 male + 60 female). The first main group had been treated with cadmium (cd+), while the other with cadmium and vitamin E (Vit E). Each main group had been divided into four subgroups, each one contains (10female + 15male). The first subgroup was regarded as control, which had free metals distilled water, while the three others subgroups were treated with D.W. which contain (10, 50, 100 ppm cd+) respectively. Also, the other main group were divided into four subgroups, the first one as control, while the others were treated with cd+ and Vit E. which were added to the drinking water in concentrations (10 ppm cd+ +50 ppm Vit. E, 50ppm cd+ + 50 ppm Vit. E and 100ppm+ cd+ +50 ppm Vit. E) respectively. After 8 weeks of treatment, half of males had been dissected for study from subgroups, the other half had mated (one male with three female). The study showed a significant weight loss as the concentration of cd+ increased in the first main group, while the results of the second main group that treated with cd+ and Vit. E, showed no loss of weight compared with control group. Also, cd+ )had an obvious effect on weight, number and mortality of fetus in the fourteenth day pregnancy in the first main group, this effect increases of cd+ concentration, while there was no effect of cd+ and Vit.E. Results showed that number and activity of sperms had significant decrease, also results showed that cd+ had a great effect on apportion and causing falling of the seminiferous liquid quality.This study showed that Vit E had an effect to repair all destruction and protect body tissue from cd+ effects. Also, Vit E increase cell capacity to resist the oxidant effect of cd+ this may protect the reproductive system, this has been noticed in the increase weight average, sperm numbers, sperm activity, thus it will increase male fertility that treated with cd+ and Vit E. also in this group there was decrease in fetus mortality compare with the first group.
Keywords
Negative effects of cadmium; Vitamin E and Antioxidant

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