| Collected 155 clinical samples were included (burns, wounds, ear infections swabs, urine and sputum) from Kirkuk and Erbil hospital patients, the isolated bacteria were diagnosed by culture, microscopic characteristics and biochemical tests, 47 (30.32%) P.aeruginosa isolation were obtained, samples and highest proportion of isolated bacteria recorded in a burns 40%, and the second highest recorded in wounds samples 35%, While sputum sample recorded lowest result 20%, Varied isolates resistant to antibiotics if indicated antibiotic Cephalexin, Amoxicillin, Tetracycline, Erythromycin, Piperacillin, resistance to 100%, While the isolates were sensitive to antibiotics for Co-Trimoxazole, Ciprofloxacin, Ceftazidime (25.53, 23.40, 23.40)% respectively, Alcoholic extract of the Capparis spinosa and dates vinegar solution effect on the sensitivity of the isolates P.aeruginosa as shown sensitivity 100%, The results showed the synergistic effect between antibiotics and alcoholic extract for capparis spinosa and dates vinegar solution, It found a significant effect on the synergy between the alcoholic extract of capparis spinosa with Piperacillin, Ciprofloxacin, Erythromycin, Tetracycline, Gentamycin, Co-Trimoxazole, It also found a significant effect on the synergy between the dates vinegar solution with Ceftazidime, Gentamycin, Rifampicillin, Piperacillin, Tetracycline, Cephalexin towards for isolates P.aeruginosa from clinical specimens |