- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
THE CORRELATION BETWEEN ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY AND TWO CYTOKINES (IL-18, TNF-Α) IN RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS DISEASE | ||
| AL-TAQANI | ||
| Article 1, Volume 26, Issue 3, 2013, Pages 0-0 | ||
| Author | ||
| Dina Adnan Abdullah AL-Roubaey | ||
| Abstract | ||
| Glomerulonephritis is the commonest cause of end-stage renal failure, all types of rapidly progressive glomerulonephritis (RPGN) are characterized by glomeruluar injury and the formation of crescents, anti-neutrophil cytoplasmic antibodies( ANCA), interleukin-18 (IL-18) and tumor necrosis factor-α (TNF-α) plays a damging role in crescent glomerulonephritis. This study was conducted to evaluate the diagnostic value of ANCA measurement, the serum levels of two cytokines( IL-18,TNF-α) and the realtionship between them in RPGN disease. The mean serum level of IL-18 and TNF-α showed significant increased level in patients with RPGN disease as compared to healthy controls, as well as, the same cytokines showed significantly increased levels in perinuclear anti-neutrophil cytoplasmic antibodies (p-ANCA) positive serum in rapidly progressive glomerulonephritis (RPGN) patients as compared to ANCA –negative serum in RPGN patients, these results indicate a functional role of IL-18 and TNF in ANCA-mediated neutrophil activation by the interdependence of IL-18 and TNF priming for ANCA responses. | ||
|
Statistics Article View: 136 PDF Download: 103 |
||