SCREENING OF CELIAC DISEASE IN IRAQI PATIENTS WITH TYPE 1DIABETES MELLITUS

Naji Abdullah, Hanaa; Jabbar Saber, Hanaa; Ali Hussein, Median

	SCREENING OF CELIAC DISEASE IN IRAQI PATIENTS WITH TYPE 1DIABETES MELLITUS
AL-TAQANI
Article 1, Volume 26, Issue 3, 2013, Pages 0-0
Authors
Hanaa Naji Abdullah; Hanaa Jabbar Saber; Median Ali Hussein
Abstract
Type 1 diabetes mellitus is a chronic autoimmune disease associated with selective destruction of insulin-producing pancreatic β-cells. The prevalence of celiac disease in patients with T1DM is approximately 20 fold that in the general population, ranging between 2%-6%. One hundred patients with type 1 diabetes mellitus and fifty apparently healthy volunteers were screened for celiac disease using the IgA, IgG anti-gliadin, antitissue transglutaminase and total serum IgA. The mean level of C-peptide among diabetic patients in comparison with healthy control which was (0. 901±0.088 ng/ ml) vs. (0.691±0.120ng/ml) (P< 0.0001). Anti-gliadin positivity in the current study showed (30%) for diabetic cases with non significant difference. Frequency of anti- tissue tranasglutaminase antibody positivity for diabetic patient's sera was (35%) while the control groups was 0.0% for healthy cases. It is clear that the concentration of IL-6 was highly elevated in the sera of diabetic patients with positive anti-tissue transglutaminase in comparison with diabetic patients without anti-tissue transglutaminase with significant differences (P<0.001). Additionally, there is non significant differences in the concentration of IgA in the sera of diabetic patients in comparison with healthy group. On the other hand, there was a highly significant finding between (AGA and Anti-tTG),( AGA and IgA) that were detected among diabetes patients (P<0.001).
Keywords
Word; Celiac disease; anti; gliadin; tissue tranasglutaminase

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