THE ROLE OF CAGA+ STRAINS IN THE IMMUNE RESPONSE IN HELICOBACTER PYLORI PATIENTS

M Ghadhban, Jasim; Abd Ali Khudaer, Hassan; Mohammed Sheet, Madha

	THE ROLE OF CAGA+ STRAINS IN THE IMMUNE RESPONSE IN HELICOBACTER PYLORI PATIENTS
AL-TAQANI
Article 1, Volume 27, Issue 2, 2014, Pages 0-0
Authors
Jasim M Ghadhban; Hassan Abd Ali Khudaer; Madha Mohammed Sheet
Abstract
The aim of this study was to elucidate the role of certain host factors (IL-17A and Treg), and bacterial factor (CagA) in the immunity against Helicobacter pylori (Hp) associated diseases. Sixty dyspeptic patients (as diagnosed by endoscopy and confirmed by histopathology) and thirty apparently healthy individuals were enrolled in this study. All subjects were evaluated for their serum IgG anti-Hp, IgG anti-CagA, and IL-17A, and blood Treg cells. The results reveal positive IgG anti-Hp in 92.5% of Hp patients among which 40.8% was CagA+. The frequency and the mean titer of IL-17A as well as the Treg cell count were significantly high among the Hp-patients. This was true for the Treg: IL-17A ratio. However, no significant difference for such results was noticed between the CagA+ and CagA- strains. Finally, the IgG anti-Hp titer was significantly higher in CagA+ than CagA- patients for cases with gastritis and gastric ulcer. In conclusion, detection of IgG anti-Hp in dyspeptic patients is helpful in the diagnosis of Hp-associated diseases and avoidance of endoscopy and biopsy. Treg cell count and IL- 17A level are both high in the Hp patients indicating that both play an impairment role of the host's immune mechanisms in eradication of the bacteria. CagA+ strain of Hp is not a sufficient indicator for the prediction of the type and severity in Hp-associated disease, however, this strain type plays a role in the modulation of the immune response through induction of high titer of IgG anti-Hp.

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