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EVALUATION OF SERUM OSTEOPONTIN LEVEL IN OBESE IRAQI POSTMENOPAUSAL WOMEN WITH PRIMARY OSTEOPOROSIS | ||
| AL-TAQANI | ||
| Article 1, Volume 27, Issue 2, 2014, Pages 0-0 | ||
| Author | ||
| Manal kamal Rasheed | ||
| Abstract | ||
| Background: Osteoporosis (OP) is a chronic and progressive disease characterized by decreased bone mass and micro architectural deterioration of bone tissue, resulting in an increased risk of fracture .Body mass index (BMI) has been found to be related to the risk of osteoporotic fractures in women, regardless of bone mineral density (BMD). Very few studies have investigated the comparison of fracture risk among BMI categories, classified according to the WHO criteria, despite the potential usefulness of such information for clinical purposes. Osteopontin was described as a major component protein in bone and named bone sialoprotein1 it’s produced by osteoblasts and osteoclasts. It has been found to be associated with bone strength and bone remodeling. OPN influences bone homeostasis both by inhibiting mineral deposition, by promoting differentiation of osteoclasts and by enhancing osteoclast activity | ||
| Keywords | ||
| Osteopororosis; Osteopontin; postmenopausal women; Obesity | ||
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