SERUM LIPID PROFILE IN PRE AND POSTMENOPAUSAL WOMEN IN RELATION TO SOME HORMONAL CHANGES

A.K. Adday, Alaa; A.H. Khalil, Sajedah; S. Yassen, Najah

	SERUM LIPID PROFILE IN PRE AND POSTMENOPAUSAL WOMEN IN RELATION TO SOME HORMONAL CHANGES
AL-TAQANI
Article 1, Volume 28, Issue 2, 2015, Pages 0-0
Authors
Alaa A.K. Adday; Sajedah A.H. Khalil; Najah S. Yassen
Abstract
Dyslipideamia is an important major risk factor for cardiovascular disease (CVD), which is the leading cause of death in the developed and developing countries. The World Health Organization estimates that dyslipideamia is associated with more than half of global cases of ischemic heart disease and more than 4 million deaths per year. We had our study to assess the serum lipid profile in pre and postmenopausal women and its association with the changes of FSH, E2 and testosterone levels. Lipid profile and pituitary- ovarian hormones was measured in 75 menopausal women age (48-65year) old and 30 premenopausal women, healthy volunteers, serving as a control group their age were (20-45year). Full history was taken, complete clinical examination was done and various laboratory examinationswere carried for all individuals in both groups. The levels of highly significant differences (P= 0.0005) were found in the menopausal women higher for the levels of TC, TG, LDL-C, VLDL-C, FI and lower HDL, (209.06 ± 40.921, 130.09 ± 62.435, 139.48 ± 39.85, 25.86 ± 12.4, 3.30 ±1.88, 36.56 ± 6.359), compared with the control group (168.83± 19.725, 85.76 ± 23.14, 108.95 ± 19.66, 17.15 ± 4.628, 2.06 ±0.62, 42.3 ± 6.325) respectively. The obese menopausal women had significantly less HDL (34.346 ± 4.76) than over weight (39.8 ± 6.98) and normal BMI (44.875 ± 5.19), (P=0.0005). In menopausal women the HDL was increasing a strong negative correlation with age, (P=0.0005). The menopausal women had Significant increase in TG, VLDL and FI with significant decrease in HDL in hypertensive (159.81 ± 80.51, 31.625 ±16.169, 4.635 ± 2.617, 35.87 ± 6.95) than non-hypertensive women (122.03 ± 54.65, 24.30 ± 10.827, 2.94 ± 1.45, 37.44 ± 6.62) respectively, (P < 0.005). The HDL showed a significant decrease among women who had more than 5 years duration of menopause (33.0±3.4) than women with less than 5 years menopause (40.628±6.53), (P <0.05).The study concluded there is a significant relationship between dyslipideamia and menopause process.A strong relationship exists between HDL and other risk factors of menopause like: obesity, hypertension, duration of menopause and older age group

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