Detection of Hematological Biomarkers Associated with Lupus Nephritis in a sample of Iraqi Patients

A. Majeed, Wasan; M. Jasim, Hameed; A. Farhan, Abbas; S. Ali, Ala; I. Gorial, Faiq

	Detection of Hematological Biomarkers Associated with Lupus Nephritis in a sample of Iraqi Patients
Jornal of Biotechnology Research Center
Article 1, Volume 11, Issue 2, 2017, Pages 56-61
Authors
Wasan A. Majeed; Hameed M. Jasim; Abbas A. Farhan; Ala S. Ali; Faiq I. Gorial
Abstract
This study was conducted on a sample of Iraqi patients with systemic lupus erythematosus (SLE) for both lupus arthritis and lupus nephritis. Blood samples were collected from 32 lupus arthritis patients with age ranged between 13 and 50 years, Female percentage was 96.87%. Another 32 blood samples were collected from lupus nephritis patients with age ranged between 16 and 65 years; Female percentage was 90.62%. For comparison, a total of 32 blood sample were also collected from normal individuals (healthy controls), with age ranged between 21 and 54 years, Female percentage was 53.12%. Relationship was studied between clinical blood parameters like total counts of white and red blood cells and platelets, hemoglobin concentration and erythrocytcite sedimentation rate (ESR) and the incidence of SLE. Results showed that there is no significant difference between count of WBC in lupus arthritis (8.47× 103 cell/ml ) and lupus nephritis patients (9.13× 103 cell/ml) and healthy controls (7.99× 103 cell/ml), while it was found that there is a significant decrease (P<0.01) in RBC count for both lupus arthritis (4.41× 106 cell/ml) and lupus nephritis patients (4.32× 106 cell/ml) in comparison with RBC count in healthy controls (4.98× 106 cell/ml). Results also showed that there is a significant decrease (P<0.01) in hemoglobin concentration in serum sample for both lupus arthritis (11.83g/dl) and lupus nephritis patients (11.79g/dl) in comparison with hemoglobin concentration (13.69g/dl) in healthy controls. On the other hand it was found that there is no any significant difference between platelets count in lupus arthritis (270.81×103 platelet/ml) and lupus nephritis patients (255.01×103 platelet/ml) and normal healthy controls (275.94× 103 platelet/ml). Results also showed that there is a significant increase (P<0.01) in ESR for both lupus arthritis (38.53mm/hr) and lupus nephritis patients (44.0 mm/hr) in comparison with ESR for healthy controls (13.09mm/hr). According to these results, clinical blood parameter including RBC count, hemoglobin concentration and ESR were regarded a clinical parameter for detecting SLE in Iraqi patients.
Keywords
Lupus Erythematous; Lupus arthritis; Lupus nephritis; hematological biomarkers

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