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Spectrophotometric determination of drug compounds in pure forms and in the pharmaceutical preparations | ||
| karbala journal of pharmaceutical sciences | ||
| Article 1, Volume 8, Issue 12, 2017, Pages 1-14 PDF (0 K) | ||
| Author | ||
| Qabas Naji Rashid | ||
| Abstract | ||
| A sensitive, rapid and economical spectrophotometric processes for estimation of two drugs; methyldopa (MTD) and Fluvastatin Sodium (FLV), by “Sodium 1,2- naphthoquine- 4-sulfonate (NQS)” as reagent in an alkaline interemediate. These methods are digested on the forming of “complexes” among these drugs and the chromogenic reagent (NQS). Orangish-brown colored complex formatted at (pH 12) and λmax. 462 nm for (MTD), and orange colored at (pH 11.7) and λmax. 466 nm for (FLV). Beer’s Law is obeyed in a concentrations range of (4-40 μg/mL), (16- 64 μg/mL), with molar absorptivity (14.101×104 L/mol.cm), (22.7×104 L/mol.cm), and correlation coefficient 0.9995, 0.9987, successively, The detection limit and quantification limit were (1.03×10-1 μg/mL, 3.12×10-1 μg/mL ), and (1.36×10-1 μg/mL, 4.12×10-1 μg/mL ), successively. The suggested methods were prosperity implement to the estimation of “these drugs” in pure forms and in their pharmaceutical formulations. | ||
| Keywords | ||
| spectrophotometric; Methyldopa; Fluvastatin Sodium; NQS reagent; NQS | ||
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