Use of intravenous paracetamol infusion versus placebo in acute brain injury

Ahmed Jawad, Samer; Abdul Kareem Mohammed, Zahraa; Mahdi, Maysaasalih; Mijbil Ubaid, Moayad

	Use of intravenous paracetamol infusion versus placebo in acute brain injury
karbala journal of pharmaceutical sciences
Article 23, Volume 8, Issue 13, 2017, Pages 258-266 PDF (0 K)
Authors
Samer Ahmed Jawad; Zahraa Abdul Kareem Mohammed; Maysaasalih Mahdi; Moayad mijbil Ubaid
Abstract
Background:Traumatic brain injuries (TBI)are main causes of mortality and disability worldwide, particularly in children and young adults. They lead to changes in temperature,cerebral blood flow,the pressure inside the skull and consciousness.Patients with TBI experience febrile episodes which lead to previous consequences so it should be resolved prophylactically by use an appropriate antipyretic, but remains important deficiency of coherent evidence about active therapies in the acute care of patients with TBI. Objectives:Early administration of intravenous paracetamol to patients to reduces core body temperature following intense traumatic brain injury contrast to placebo (normal saline). Patients & Methods: Involved in this study 20 patients of both sex, aged from 18 to 65years, who were accepted to the intensive care unit for sharp brain injury. A prospective study was carried out in intensive care unit in AL Hussein medical city in Karbala during the period from first of November 2016 to the 28Th of February 2017. Eligible patients wererandomly selected & classified to two groups A & B which (10 patients each group). Group A received (0.9 %) of sodium chloride (normal saline) each(6 /24) hours and group B received 1gram of intravenous Paracetamol every (6 /24) hours. The result included Temperature, pulse rate and systolic & diastolic of blood pressure, which were measured prior to administration of the study drug, hourly during the period of study (24 hours) & till 2 hours after the final dose of the study. The data were analyzed by using T-test. Results: By using T-test of two groups. Shows this study that there is little or no significant decrease in patient’s temperature in group B who were given paracetamol (P>0.05) except at (first dose) of paracetamol (P< 0.05), while there is no change in group A who were given normal saline (P>0.05).This study also shows significant decrease in diastolic blood pressure in group B at (first & second dose) of paracetamol (P<0.05), while there is no significant change in group A (P>0.05). When we monitored the pulse rate parameter & systolic blood pressure, we noticed that there is no significant change in its value in the two groups (P>0.05). Conclusion:. Was concluded that there is little or no significant decrease in patient’s temperature in group B who were given paracetamol, while there is no change in group A who were given normal saline.
Keywords
Traumatic brain injury; paracetamol; normal saline and Fever

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