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Synthesis of some New Fused Pyrimidine Compounds | ||
| Rafidain Journal of Science | ||
| Article 11, Volume 26, Issue 1, 2017, Pages 92-99 PDF (0 K) | ||
| DOI: 10.33899/rjs.2017.139098 | ||
| Authors | ||
| Shaymaa K. Younis* 1; Maysaa K. Shaker2 | ||
| 1Department of Chemistry, College of Science, University of Mosul | ||
| 2Department of Chemistry, College of Education for Girls, University of Mosul | ||
| Abstract | ||
| Biginelli reaction is a one-pot reaction which is used to prepare some of fused pyrimidine (2-Amino-4-aryl-7, 7- dimethyl-1, 4, 5, 6, 7, 8-hexahydro quinazoline-5-one) (A1-6) by the action of dimedone, guanidenium hydrochloride and some substituted benzaldehyde in presence of Lewis acid represented by boric acid (20% mole). These compounds were used later as precursors to prepare a superim type of schiff bases represented by compounds (2-Amino-4-aryl-5-hydrazono-7, 7-dimethyl-1, 4, 5, 6, 7, 8-hexahydro quinazoline) (B1-6). The assigned structure of the prepared compounds was corroborated by available physical and spectral methods. | ||
| Keywords | ||
| Biginelli reaction; dimedone; guanidenium hydrochloride; Schiff bases | ||
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