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Enhancement of bone induction after implantation of amelogenin protein and its active sub-protein. | ||
| Journal of baghdad college of dentistry | ||
| Article 1, Volume 20, Issue 1, 2008, Pages 21-23 | ||
| Author | ||
| Riyadh O. Alkais | ||
| Abstract | ||
| ABSTRACTBackground: Amelogenin (AM),a major enamel matrix protein(EMP),is a potent bone morphogenic protein which can enhance bone formation, and contains an active sub-protein(AAS).Materials and methods: Twenty adult Syrian hamsters were grouped into 2, groups. Two holes were induced in the mandible of each animal and 3 mgs of AM &AAS were applied in each whole of, group 1 and group 2 respectively. Animal scarifying was done after 3, 7, 14, 21 and 28 postoperatively, serial sections were prepared and slides were examined by light microscope.Results: Comparison of osteoinductive activity of whole AM protein (complex) with that of its intermediate molecular weight sub-protein (active sub-protein (AAS) revealed that the osteoinductive process was more accelerated after AM application than that after AAS applicationConclusions: Other AM sub-proteins may act collectively with AAS to represent the excellent osteoinductive activity of AM protein.Key words: Amelogenin, bone morphogenic factor, active sub-protein. (J Bagh Coll Dentistry 2008; 20(1) 21-23) | ||
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