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Immunohistochemical Localization of Epstein Barr VirusLatent Membrane Protein 1 in Breast Cancer Tissues | ||
| Iraqi Postgraduate Medical Journal | ||
| Article 1, Volume 15, Issue 2, 2016, Pages 234-240 PDF (375.44 K) | ||
| Authors | ||
| Saad Hasan Mohammed Ali; Shakir H. Mohammed Al-Alwany; Ghanim I.A. Al-Wadi | ||
| Abstract | ||
| BACK GROUND: Epstein- Barr virus (EBV) is well known to infect the vast majority of the world's adult population and has recently been reported in many literatures for its association with a broad spectrum of benign and malignant tumors, including breast cancer. OBJECTIVE: To analyze the relations and impact of Epstein Barr Virus- latent membrane protein 1(EBV-LMP 1) expression on a group of tissues with primary invasive breast cancers. PATIENTS AND METHODS: Forty- nine (49) formalin-fixed, paraffin- embedded breast tissues were obtained in this study; (34) biopsies from breast cancers (BC) and (15) from apparently normal breast autopsies control group. Detection of expression of Epstein Barr Virus- latent membrane protein 1(EBV-LMP 1) was done by HRP/DAB immunohistochemistry detection kit (an immunoenzymatic antigen detection system for immunohistochemistry techniques) using specific primary antibodies for EBV-LMP 1. RESULTS: Detection of EBV-LMP 1 - immunohistochemical (IHC) reactions in tissues with BC was observed in 11 out of 34 (32.4%), while in healthy breast tissues in the control group was detected in 13.3% (2 out of 15). The difference between the percentages of EBV-LMP 1 detection in BC tissues & control group was statistically not significant (P >0.05). While no significant differences were observed between EBV-LMP 1 detection in BC tissues & the age of patients as well as grade of invasive breast cancers (P value > 0.05). CONCLUSION: Our results indicate that EBV could have a role in the pathogenesis of subset of breast cancers and contribution in their carcinogenesis. | ||
| Keywords | ||
| breast cancer; epstein barr virus; ebv - latent membrane protein 1; immunohistochemical technique. | ||
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