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Study the expression of PGBD3 Neogene, which derived from DNA transposons in Leukaemia cell lines | ||
| AL-yarmouk Journall | ||
| Article 1, Volume 9, Issue 9, 2017, Pages 151-157 | ||
| Author | ||
| Ahmed H. Qasim | ||
| Abstract | ||
| The process of molecular domestication that occurs in some DNA transposons which leads to the production of genes called neogenes. These neogenes may play an important role in the human genetic instability. One of these Neogene is piggyBac 3 (PGBD3), which is associated with human Cockayne syndrome and premature ovarian failure. Aim: To study the expression of PGBD3 Neogene in leukaemia cell lines. Method: By western blot method we study the protein expression of PGBD3 gene in seven leukaemia cell lines (HL60, NB4, KG1, KG1a, ML2, THP1 and U937) and in healthy tissue of blood (blood sample taken from healthy person) as a control in this study. Results: We obtained a protein expression of PGBD3 gene in all seven leukaemia cell lines with variable degree of expression which was not seen in healthy blood tissue. Conclusion: PGBD3 gene may have a role in blood cancer either in initiation, promotion or progression, which needs further research and confirmation. | ||
| Keywords | ||
| DNA transposons; domestication; Neogene; PGBD; microsatellite instable; microsatellite stable; and leukaemia cell lines | ||
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