T. Mashkour, K., A. Sultan, B., M. Jasim, A. (2009). Competitive Inhibition Relationship Between Erythropoietin And Interferon-Gamma In Renal Failure Anemia. , 5(2), 1-7.
Kareem T. Mashkour; Baqur A. Sultan; Ali M. Jasim. "Competitive Inhibition Relationship Between Erythropoietin And Interferon-Gamma In Renal Failure Anemia". , 5, 2, 2009, 1-7.
T. Mashkour, K., A. Sultan, B., M. Jasim, A. (2009). 'Competitive Inhibition Relationship Between Erythropoietin And Interferon-Gamma In Renal Failure Anemia', , 5(2), pp. 1-7.
T. Mashkour, K., A. Sultan, B., M. Jasim, A. Competitive Inhibition Relationship Between Erythropoietin And Interferon-Gamma In Renal Failure Anemia. , 2009; 5(2): 1-7.

Competitive Inhibition Relationship Between Erythropoietin And Interferon-Gamma In Renal Failure Anemia

Al-Qadisiah Medical Journal
Article 1, Volume 5, Issue 2, 2009, Pages 1-7    PDF (0 K)
Authors
Kareem T. Mashkour; Baqur A. Sultan; Ali M. Jasim
Abstract
This is an in vitro laboratory study. It was done in order to prove the competitive inhibition between interferon-gamma (IFN-gamma) and erythropoietin (EPO) in chronic renal failure (CRF) by fixing an inhibition elicited by EPO on IFN-gamma expression by mononuclear cells. These cells were already separated from fresh anticoaggulated blood specimens from nine CRF-patients and nine healthy persons.Then, were co incubated separately with mitogen, phytohemaggluttinin with and without EPO under standard incubation conditions. Thereafter, IFN-gamma level was measured by ELISA. Results have shown that EPO significantly inhibits IFN-gamma expression by mononuclear cells in healthy persons, p value < 0.05, while this inhibition is not significant in CRF-patients.
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