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Evaluation of Some Immunological Tests for Early Diagnosis of Bacterial Neonatal Sepsis | ||
| Al-Qadisiah Medical Journal | ||
| Article 1, Volume 6, Issue 2, 2010, Pages 67-80 PDF (0 K) | ||
| Authors | ||
| Manal Mohammed Kadhim; Jaafar Kadhim AlMousawi | ||
| Abstract | ||
| Abstract: Neonatal sepsis is a major cause of death in newborns despite sophisticated neonatal intensive care. This cross-section study was done on 69 neonates with suspected sepsis who were admitted in Neonatal Intensive Care Unit (NICU) of Maternity and Child Teaching Hospital at AL-Diwaniya city, and 20 healthy neonates as a (control group) in the period from March to October 2009.This study was conducted to evaluate the diagnostic value of some immunological marker such as (CRP,IL-6, IL-8,TNF-α, in the early diagnosis of neonatal sepsis prior to the blood culture ( the golden standard test). The culture positivity rate 20 (28.9%) among suspected sepsis neonates, the male more affected than female among proven sepsis. it was found that the median concentration of CRP, TNF-α, IL-8, IL-6 decreased in order of definitive infection, clinical sepsis and healthy subjects respectively (P<0.001), and found that the TNF-α (≥65.4pg/l) followed by IL-8 (≥60.9pg/l) were better than IL-6 and CRP with sensitivity of (80%) and (75%) respectively and negative predictive value of (97%) and (94.1%) respectively when used as a tests to predict culture positive sepsis cases differentiating them from culture negative sepsis cases . | ||
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