The Effect of Citric Acid on some Biochemical Parameters in Male Rabbit

G. Taha, Intisar

doi:10.33899/rjs.2018.141068

	The Effect of Citric Acid on some Biochemical Parameters in Male Rabbit
Rafidain Journal of Science
Article 23, Volume 27, Issue 1, 2018, Pages 10-16 PDF (414.98 K)
DOI: 10.33899/rjs.2018.141068
Author
Intisar G. Taha
Abstract
The research includes the study of side effect of citric acid by giving different concentrations at various duration time on some biochemical parameters which has related to the liver function in serum and tissue of liver. Six month aged healthy male rabbits with weight ranged between 1-1.5 kg were used in this research. They were distributed randomly into four groups; The first group was given distilled water as a control group, the second group was given a dose of 250 mg/kg of body weight of citric acid, the third group was given a dose of 500 mg/kg of body weight of citric acid and the fourth group was given a dose of 1000 mg/kg of body weight of citric acid. Acid was added to drinking water of all groups for 30 days with providing food freely to the animals as long as the experiment lasted. After blood was drawn out and serum was taken male rabbits were killed. The results showed that no signification in level of total protein and albumin in different concentration and different duration time comparing with the control group. A lso the results showed significant increase of alanine aminotransferase ALT and aspartate aminotransferase AST activity, and malonaldehyed MAD in liver tissue compared with the control group. A significant decrease in the level of glutathione GSH in liver tissue was also seen comparing with the control group with increase concentration of citric acid and increase duration time of treatment
Keywords
Citric acid; Total protein; Albumin; ALT; AST; MAD; GSH

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