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Synthesis and Spectral Characterization of a New Series of N-4-Chlorobenzamide-5- phenylthiazolidin-3-one | ||
| Rafidain Journal of Science | ||
| Article 3, Volume 27, Issue 1, 2018, Pages 15-28 PDF (0 K) | ||
| DOI: 10.33899/rjs.2018.141182 | ||
| Authors | ||
| Kezhal M. Salih; Hashim J. Azeez | ||
| Abstract | ||
| A new series of 4-thiazolidinones (4a-j) has been synthesized by cyclocondensation of various acid hydrazones with thioglycolic acid. The intermediate hydrazones (3a-j) were synthesized by the condensation of various substituted benzaldehydes with 4-chlorobenzohydrazide (2). The starting compound 4-chlorobenzohydrazide was prepared from the reaction of ethyl 4-chlorobenzoate and hydrazine hydrate. The structures of the new synthesized compounds had been confirmed by spectral data (FTIR, 1H-NMR, 13C-NMR, and 13C-NMR –DEPT and ESIMS). Some of the synthesized compounds (4a-j) were evaluated for their antibacterial activity against Gram-positive bacteria staphylococcus aureus and Gram – negative psedomonas aeruginosa | ||
| Keywords | ||
| Acid hydrazone; Thiazolidinone | ||
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