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A Study of P 53 codon (72) polymorphism distribution and related risk factors in Kerbala population by PCR | ||
| Albahir journal | ||
| Article 1, Volume 5, Issue 9, 2017, Pages 81-90 | ||
| Author | ||
| Hassan Mahmood Mousa Abo Almaali | ||
| Abstract | ||
| Tumor protein (53) P53 is a member of family of proteins responsible for many processes such as preventing cancer by controlling cell cycle, programmed cell death (apoptosis), stress response, DNA repair and gene expression. It’s found that p53 have many codons that may be subjected to mutation by many factors and these mutation may lead to cancers in many systems of human body.One of most important sites of mutation responsible for cancer development is codon (72) because it located on exon (4).Codon (72) has three polymorphisms which are R/R, R/P and P/P according to arginine substitution with proline in the proline’s rich area.The present study aimsto study the distribution of codon (72)polymorphisms in Kerbala population and impact of many risk factors such as smoking, diseases with genetic extension such as diabetes mellitus and hypertension in addition to another factor such as age, residency, academic achievement and gender on polymorphism of codon (72) of p53.Our study showed there is only two types of codon (72) polymorphisms has been found in our cases, which are R/R and R/P, P/P alleles not found in studied population. The results also revealed that no strong association between one type on codon (72) polymorphisms and the studied risk factors, such as smoking, diseases with genetic causation (such as diabetes mellitus and hypertension) and other factor such as age, residency, academic achievement that we are study. The correlation coefficients (r) were as the following; the smoking status/ polymorphism (r=0.07141);education /polymorphism (r=0.10955); age /polymorphism correlation (r=-0.0636); and gender /polymorphism (r=0.1). | ||
| Keywords | ||
| codon | ||
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