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Study the Histological Effect of the Oxytetracycline Antibiotic in Kidneys of the Local Rabbit Males Oryctolagus cuniculus | ||
| Journal of Tikrit University For Agriculture Sciences | ||
| Article 1, Volume 18, Issue 1, 2018, Pages 172-182 | ||
| Authors | ||
| Makarim M. Kamal; Ayad H. Ibraheem; Esmat J. Jameel | ||
| Abstract | ||
| The present study was conducted during August 2015 to February 2016 at Kirkuk University laboratories to determine the effect of Oxytetracycline in rabbit kidneys, to determine the safe dose for use in the animals. Two doses were administered, one by injection of the muscle and the other by oral administration. In the study, 56 rabbits were divided into four groups, the first group was injected with distilled water, and the other three doses were administered once daily for 15 days at 5%, 20%, 50% mg / kg Of body weight) respectively. Animals were killed on different dates 7, 30 and 60 days after the end of the dosage. The results showed the presence of changes in the kidney tissue, which consisted of renal glomerular degeneration and congestion, as well as inflammation of the inflammatory cells, with the dilated of Bowman's capsule and the Desquamation of the Endothelium of the Urinary Tubules in the Kidney and their swelling, With an increase in urinary tubular degeneration due to increasing concentration of doses and duration of killing, as well as the presence of protein substances in the cavities and the occurrence of Coagulative Necrosis after 60 days. | ||
| Keywords | ||
| Histology; antibiotic; kidney; Rabbit | ||
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