Evaluation of salivary enzymes activities among patients with chronic periodontitis

A. Alsafi, Khulood; J. Abdul-Hadi, Mustafa

	Evaluation of salivary enzymes activities among patients with chronic periodontitis
Journal of baghdad college of dentistry
Article 1, Volume 22, Issue 1, 2010, Pages 65-67
Authors
Khulood A. Alsafi; Mustafa J. Abdul-Hadi
Abstract
ABSTRACTBackground: The cells of periodontium contain many intracellular enzymes like (alkaline phosphatase ALP, aspartateaminotransferase AST and alanine aminotransferase ALT) that are released outside into the saliva and gingivalcrevicular fluid GCF after destruction of periodontal tissue during periodontitis. The aim of this study is to determinethe activities of these enzymes in saliva and its relation to the clinical periodontal parameters during chronicperiodontitis.Materials and methods: Measurements of plaque index (PLI), gingival index (GI), bleeding on probing (BOP), probingpocket depth (PPD) and clinical attachment level (CAL) were taken from sixty subjects (thirty with chronicperiodontitis and thirty with healthy periodontium), only male were included and saliva was collected from them andsubjected to biochemical analysis of the enzymes alkaline phosphatase ALP, aspartate aminotransferase AST andalanine aminotransferase ALT levels.Results: Statistical analysis of the results revealed the presence of a highly significant difference in the enzymaticactivity between healthy and chronic periodontitis subjects with absence of any correlation between the activities ofthese enzymes and the clinical periodontal parameters except between alanine aminotransferase ALT and PLI(Pvalue :0.049) and between alkaline phosphatase ALP and BOP (P value: 0.041).Conclusions: It can be concluded that these enzymes are good biochemical markers and helpful in early diagnosisof chronic periodontitis.Key words: Saliva, enzymes, chronic periodontitis. J Bagh Coll Dentistry 2010; 22(1):65-67.

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