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Relationship between interlukine- 1 alpha andpolyamines levels in serum and saliva as potentialbiomarkers in the diagnosis of oral squamous cellcarcinoma | ||
| Journal of baghdad college of dentistry | ||
| Article 1, Volume 22, Issue 1, 2010, Pages 50-54 | ||
| Authors | ||
| Abdul-W. R. Hamad; Nazar G. Al-Talabani; ShanazM. Gaphor | ||
| Abstract | ||
| ABSTRACTBack ground: Oral cancer is one of the prevalent cancers of the body and is one of the 10 most commoncauses of death. Oral squamous cell carcinoma (OSCC) accounts for over 90% of these tumors. The aim of thisstudy was designed to detect biochemical markers in serum and saliva of oral squamous cell carcinomapatients and to evaluate their validity in monitoring and diagnosis and to correlate relation ship between IL-1alpha and polyamines. .Patients and Methods: The level of polyamines in the serum and saliva of (30) patients with OSCC and (20)healthy individuals as control group was measured. Level of proinflammatory cytokine Interleukin 1α (IL-1α) wasdetected by enzyme linked immunosorbent assay (ELISA). Polyamines (spermidine and spermine) weredetermined by high performance liquid chromatography (HPLC) in both serum and saliva of patients with OSCCand control group.Results and Discussion: Salivary IL-1 alpha was useful in the diagnosis of OSCC patients. The total serum andsalivary polyamines level of OSCC were significantly higher than the control group (P<0.001). Both salivary andserum polyamines level were reliably accurate test in separating between OSCC patients and control group.There was significant difference in salivary spermine level among OSCC patients in relation to lesion status.Spermine levels were reduced in recurrent lesion especially with metastases. There were significant differencesin serum polyamines level among OSCC patients in relation to duration of the disease (P<0.05).Conclusion: There was a significant weak correlation between salivary IL-1α and salivary spermine (r=0.377)(p<0.05). From the results of the presents study, it can be concluded that detection of polyamines in serum andsaliva are useful and valuable diagnostic markers in diagnosis and early detection of OSCC.Keywords: Oral cancer; polyamines; Interleukin 1α (IL-1α); OSCC. J Bagh Coll Dentistry 2010; 22(1):50-54. | ||
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