Synthesis, characterization and biohydrolysis drug release studies of polymer carrier with Naproxen

M. G. Alzahawi, Hala

doi:10.32894/kujss.2018.142385

	Synthesis, characterization and biohydrolysis drug release studies of polymer carrier with Naproxen
Kirkuk Journal of Science
Article 1, Volume 13, Issue 1, 2018, Pages 79-94 PDF (0 K)
DOI: 10.32894/kujss.2018.142385
Author
Hala M. G. Alzahawi
Abstract
In the present work, the hydroxyl groups of "HPMC, HPC and HEC" polymers bonds with bioactive material "naproxen drug" by esterification process. (direct esterification and indirect esterification). The modified s polymers are characterized by some spectroscopic methods such as FTIR, UV, H1. NMR and C13. NMR. The degree of substitution (D.S) of the hydroxyl groups in suger molecule in polymer was determined in all cases. The hydrolysis of modified polymers is carried out in the heterogeneous phase in a buffer solution of pH (2.0, 7.4 and 9.0) at various temperatures (25, 37, and 45 Co). The amounts of released naproxen drugs were quantitatively determined by using calibration curve method. Biodegradation (in vitro degradation) of modification polymers is carried out by enzymatic cleavage (using lipase enzyme) at pH 7.4 (the human blood pH) and 37Co. The amounts of released naproxen were quantitatively determined by U.V visible spectrophotometry by using the usual calibration curve method. In general, it was found that the release in presence of enzyme was faster than in hydrolysis process
Keywords
modification polymer; Drugs release; naproxen

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