- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
Molecular assessment of apoptotic genes in leukemic patients | ||
| Journal Of Wassit For Science & Medicine | ||
| Article 1, Volume 8, Issue 1, 2015, Pages 105-114 | ||
| Abstract | ||
| Abstract Leukemia is one of the commonest ten cancers in Iraq and worldwide. This disease is classified into myeloid or lymphoid and they are further divided into chronic or acute leukemia. This research included chronic myeloid leukemia (CML) in fourty nine patients (22males and 27females).Multiplex polymerase chain reaction was done to analyze five human apoptotic genes (P53,Bcl2,Cmyc,ICE and GAPDH).These genes demonstrated highly significant comparing with ten control p<0.05(p=0.000, p=0.000, p=0.000, p=0.004) GAPDH regarded as internal control. While they didn’t show any significance with gender, age groups or phases except P53 was showed highly significant with blast transformation phase. These results showed that genes were expressed in patients, and these may regard as important indicators for this disease. Further studies are needed to confirm this observation and better elucidate the mechanism. The aim of this research is to study the molecular expression of apoptotic genes in leukemic patients compared with healthy controls and study the expression of apoptotic genes in leukemic patients related to gender, age groups and phases of CML. | ||
| Keywords | ||
| Key Words; CML; apoptotic genes | ||
|
Statistics Article View: 216 PDF Download: 75 |
||