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Relationship between Herpes Simplex Virus Type- 1 and periodontitis | ||
| Journal of baghdad college of dentistry | ||
| Article 1, Volume 23, Issue 1, 2011, Pages 146-150 | ||
| Authors | ||
| Sana A. AL-Shaikhly; HindWael Al-Alousi | ||
| Abstract | ||
| ABSTRACTBackground: HSV-1 is responsible for the most commonly occurring viral infections of the mouth and perioral softtissues, HSV-1which primarily is associated with oral and labial lesions, .and it causes a recurrent infection, whichcommonly occurs in the mouth. Additionally, HSV infection has been associated with periodontitis. The HSV-1 maycause periodontal pathosis as a direct result of virus infection and replication, or as a consequence of virallyinduced impairment of the periodontal immune defense, resulting in heightened virulence of resident bacterialpathogens.The aims of the study are to show the relationship between HSV-1 and periodontitis, and to determineHSV-1 Antigen in saliva of periodontitis patients by immunoflourescent, as well as to determine HSV-1 antibodiesimmunoglobulin G (IgG) in saliva samples by enzyme linked immunosorbent assay (ELISA) test.Materials and methods: Thirty periodontitis patients and thirty periodontitis patients and have recurrent herpeslabials (RHL) compare with thirty healthy control subjects were included in this study. Saliva samples were taken fromall subjects (patients and healthy) and examined by direct immunofluorescent and ELISA test. Two swabs frompatients with oral herpes labials were considered as a positive control.Results: The present study indicated that there is relationship between HSV-1 and periodontitis and the herpessimplex virus type-1 was detected in periodontitis patients by ELISA and immunofluoresecent method.Conclusion: The study revealed positive association between HSV-1 and periodontitis and the virus may play a rolein the pathogenesis of the periodontitis.Key words: HSV-1, periodontitis, ELISA, direct immunofluorescent, Saliva. (J Bagh Coll Dentistry 2011;23(1):146-150). | ||
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