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Synthesis, Characterization and Antibacterial Activity of Two Novel Azo Compounds | ||
| Almuthanna Journal of Pure Science (MJPS) | ||
| Article 1, Volume 2, Issue 1, 2014, Pages 0-0 | ||
| Author | ||
| Hasanain Gomhor Jasim | ||
| Abstract | ||
| In this study, two novel azo compounds were synthesized by diazonation of 4- aminoantipyran followed by coupling with 4-(dimethylamino)benzaldehyde and N- (4-hydroxyphenyl)acetamide. The synthesis azo compounds were characterized by IR, CHN, UV-Vis., TLC and melting points. Also, was carried out to determine the antibacterial activity of these compounds against burn infection isolated bacteria. Thirty samples were collected from patients related to Samawa-teaching hospital burn unit. Sixty five isolate from both sex males (53.33%) and females (46.66%). Staphylococcus aureus was found to be must common isolated (43.07%), then Pseudomonas aeuroginosa (21.53%), Klebsiella spp. (12.30%), E. coli (9.23%), Proteus mirabilis (7.69%), Streptococcus pyogenes (4.61%) and Aeromonas hydrophila (1.53%) . The synthesis azo compounds showed a good antibacterial activity against the isolated bacteria by using disk diffusion method. MICs values were determined for all types in broth modulation assay. | ||
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