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Role of dietary antioxidant (ascorbic acid, vit.A and alfa tocopherole) in correction of liver dysfunction resulted from oxidative stress in rabbits affected experimentally with diabetes mellitus | ||
| Almuthanna Journal of Pure Science (MJPS) | ||
| Article 1, Volume 1, Issue 1, 2013, Pages 0-0 | ||
| Author | ||
| Abd. Afrh jaleel | ||
| Abstract | ||
| Determination of reliable biochemical parameters of experimental diabetic rabbit by alloxane monohydrates on liver function and role of diatery antioxidants (ascorbic acid, vit. A, and α-tocopherole) supplementation were investigated. Body weight gain, blood (plasma) chemistries, antioxidant enzymes and histopathological lesions were determined over 10 week in newzealand white rabbit group each contain 10 animals: control G1 animals group, diabetic only G2 animals group, diabetic and ascorbic acid G3 animals group, diabetic and Vit. A G4 animals group, diabetic and α-tocopherole G5 animals group . each of dietary ascorbic acid, vit. A and α-tocopherole that given to animals of G3, G4 and G5 respectively were significantly (P≤0.01) improve body weight gain and glucose level in blood than G2 diabetic group G3 and G5 significantly did not differ but these two groups significantly more best than G4 group, also these antioxidants improve levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and total protien. Enzymatic activity of liver glutathione peroxidase and superoxide dismutase were increased significantly more than of diabetic animals G2. histopathological structures of liver and pancrease confirm these results, as generally oxidative stress that affect liver function may diminished by administration of antioxidant ascorbic acid, Vit. A and α-tocopherole supplementation, and α-tocopherole group was the best group. | ||
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