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Nucleolar organizer regions in giant cell lesions of the jaws in relation to clinico-pathological parameters | ||
| Journal of baghdad college of dentistry | ||
| Article 1, Volume 21, Issue 4, 2009, Pages 59-62 | ||
| Author | ||
| Balkees T. Garib | ||
| Abstract | ||
| ABSTRACTBackground: It is to clarify the proliferatiove activity of the multinucleated giant cells and cellular component in giantcell lesions of the jaw in correlation to their clinico-pathological features.Materials and methods: This study was carried on 23 cases diagnosed as GC lesion of the jaw. Patient's personal andclinical information were collected from their files. H&E and sliver nitrate stains were applied on their formalin fixedparaffin embedded tissue sections.Results: the mean AgNOR count in MGC/cell was 49.83 and NORs/nucleus was 5.8, and 74% of them were groupedin large clusters and 26% were scattered. In PGCG the mean AgNOR count /MGC and /nucleus were significantlylower than that of CGCL (38.2 vs 59.5 and 4.6 vs 6.8 respectively, P<0.04). The mean AgNOR count of spindle andmononuclear cells were 4.7 in CGC lesions and 2.5 in peripheral lesionsConclusion: evaluation of AgNORs showed that both MGC and fraction of mononuclear cells in CGCG weresignificantly higher than that in PGCG. (J Bagh Coll Dentistry 2009; 21(4): 59-62). | ||
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