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Dissolution Enhancement of Raltegravir by Hot Melt Extrusion Technique | ||
| Iraqi Journal of Pharmaceutical Sciences | ||
| Article 1, Volume 27, Issue 1, 2018, Pages 20-29 | ||
| Author | ||
| Ahmed S. Abdul Jabbar | ||
| Abstract | ||
| The objective of the study to develop an amorphous solid dispersion for poorly soluble raltegravir by hot melt extrusion (HME) technique. A novel solubility improving agent plasdone s630 was utilized. The HME raltegravir was formulated into tablet by direct compression method. The prepared tablets were assessed for all pre and post-compression parameters. The drug- excipients interaction was examined by FTIR and DSC. All formulas displayed complying with pharmacopoeial measures. The study reveals that formula prepared by utilizing drug and plasdone S630 at 1:1.5 proportion and span 20 at concentration about 30mg (trail-6) has given highest dissolution rate than contrasted with various formulas of raltegravir. | ||
| Keywords | ||
| Hot melt extrusion; Raltegravir; Plasdone S | ||
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