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Indirect Spectrophotometric Determination of Mesalazine via Chromate-1,5-Diphenyl carbazide Complex | ||
| Rafidain Journal of Science | ||
| Article 8, Volume 27, Issue 2, 2018, Pages 69-78 PDF (476.4 K) | ||
| DOI: 10.33899/rjs.2018.145392 | ||
| Author | ||
| Enam A. Hamdoon | ||
| Abstract | ||
| A simple and rapid indirect spectrophotometric method for the determination of mesalazine is developed. The method is based on the rapid reduction of known large amount of chromate CrO4-2 in the presence of mesalazine in acidic medium of 2N H2SO4. The excess amount of chromate is measured after it's reaction with 1,5-diphenylcarbazide which finally gives a pink-violet, water soluble and stable complex, which exhibit a maximum absorption at 546 nm. Beer's law is obeyed in the concentration range from (5-900) µg of mesalazine in a final volume of 25 ml (0.2-36 ppm) with a molar absorbtivity of 1×105 l.mol-1.cm-1, Sandell's sensitivity index of 0.0015 μg .cm-2 and relative standard deviation ± 0.0848 to ± 0.3155 depending on the concentration level. The proposed method is applied successfully to the assay of mesalazine in its pharmaceutical prepearation (capsules). | ||
| Keywords | ||
| Mesalazine; Spectrophotometic Method; Chromate; DPC; Diphenylcarbazide | ||
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