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Synthesis and Characterization of New 1,2-Dihydropyridine-3-Carbonitrile Compounds with Study of Expected Biological Activity | ||
| Journal of Al-Nahrain University - Science | ||
| Article 1, Volume 21, Issue 2, 2018, Pages 45-50 | ||
| Authors | ||
| Hiba H.Ibraheem; Yasameen K. Al-Majedy; Ali J.Salim; Redha I. Al-Bayati | ||
| Abstract | ||
| New 1,2-dihydropyridine-3-carbonitrile derivative compounds (3,4) were synthesized by cyclization of ketones (compound (1) and compound (2)) with appropriate aldehydes (4-N, N-dimethylaminobenzaldehyde and 4-chloro-2-oxo-2H-chromene-3-carbaldehyde) in presence of ethyl cyano acetate and ammonium acetate. The new synthesized compounds have been characterized using Melting point, FT-IR spectroscopy and 1H-NMR and 13C-NMR spectrum. The evaluation of biological activity of some synthesized compounds (1-4) with different concentration 10 mg mL−1, 1 mg mL−1 and 0.1 mg mL−1, against two types of bacteria on gram positive bacterial Staphylococcus aureus, Streptococcus pyogenus and gram nagetive bacterial Escherichia coli, Klebsiella pneumniae. | ||
| Keywords | ||
| Dihydropyridine; Chromen; Ones | ||
|
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