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Synthesis and Identification of Heterocyclic Compounds Derived from Ciprofloxacin | ||
| Kirkuk Journal of Science | ||
| Article 1, Volume 13, Issue 2, 2018, Pages 365-382 PDF (0 K) | ||
| DOI: 10.32894/kujss.2018.145900 | ||
| Author | ||
| Shaima Ibraheem Chyad AL-khazraji | ||
| Abstract | ||
| This research included preparation of Heterogeneous Cyclic compounds (quadrilateral and pentalateral) based on the acidic form of Ciprofloxacin (1) as a starting material. The ester compound (2) was prepared by reacting (1) with ethanol in the presence of sulphuric acid, followed by the reaction with hydrazine-hydrite to obtain the hydrazide compound (3), which was treated with aromatic aldehydes in the presence of absolute ethanol as a solvent to give the Schiff bases (4-6). The quadrilateral cyclo derivatives of B-Lactam (7, 9, 11) were prepared by reacting the Schiff bases with chloroacetyl chloride, using 1,4-dioxan as a solvent and trimethyl amine as a base. The pentalateral oxazolidine cyclo compounds (8, 10, 12) were prepared by reacting the Schiff bases with glycolic acid in the presence of 1,4-dioxan as a solvent. All prepared compounds were characterized using IR spectroscopy and melting points to prove the accuracy of the chemical structures | ||
| Keywords | ||
| Ciprofloxacincompound; Lactam derivatives; oxazolidine compound; ciprofloxacin | ||
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