- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
THE EFFECT OF DIFFERENT EXCIPIENTS ON LORNOXICAM/BACLOFEN ORODISPERSABLE TABLET | ||
| karbala journal of pharmaceutical sciences | ||
| Article 3, Volume 9, Issue 14, 2018, Pages 1-11 PDF (0 K) | ||
| Authors | ||
| Hasanain Mahmood; Ashti M.H. Saeed; Maryam Alaayedi | ||
| Abstract | ||
| Background and aim: An orally disintegrating tablet (ODT) is different than ordinary tablets since it was designed to be disintegrated in the mouth cavity rather than swallowed to stomach. ODT has been used for elder, children and patients who have swallowing difficulty. Lornoxicam is a non-steroidal anti-inflammatory drug which used as analgesic, anti-pyretic and anti-inflammatory agent. Baclofen is used as a muscle relaxant; therefore, adding baclofen to lornoxicam in the same dosage form unit could both help improve certain musculoskeletal problems and improve patient compliance. The aim of this study was to formulate ODT of lornoxicam/baclofen containing different amount and types of disintegrating agent. Method: Ten formulas of lornoxicam/baclofen ODTs using different excipients and superdisintegrants including crospovidone (CP), sodium starch glycolate (SSG), croscarmellose (CC) and banana powder in different concentrations. Different evaluation tests were performed for the tablet formulations involving tablet hardness, friability, content uniformity, weight variation, thickness, tablet disintegration and dissolution test. Results and conclusion: The results demonstrated that formula containing 5% of SSG has a better formula with disintegration time of 15 seconds and better percent of drug release reaching more than 99% of lornoxicam and more than 95% of baclofen after 45 minutes of dissolution study. All formulas have acceptable results except tablets containing banana powder since their disintegration times were more than 5 minutes. | ||
| Keywords | ||
| ODT; lornoxicam; Baclofen; disintegrating agents and banana powder | ||
|
Statistics Article View: 153 PDF Download: 101 |
||