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The protective and therapeutic effect of alcoholic extract of rosemary officinalis against degeneration effect of over dose of paracetamol on the heart muscle of rats. | ||
| karbala journal of pharmaceutical sciences | ||
| Article 4, Volume 9, Issue 14, 2018, Pages 12-22 PDF (0 K) | ||
| Author | ||
| Muntdhur Mohammad Cani | ||
| Abstract | ||
| The experiment were performed in present study to estimate the protective and the therapeutic role of ethanolic extract of rosemary (Rosmarinus officinalies) leaves against acute destructive changes in rats due to high dose of paracetamol, 1ml/ 1000mg/ kg that led to a particular aspect of heart necrosis, congestion, vacuolation of heart muscle cells, and infiltration of inflammatory cells. Leaves and stem of (Rosemary officinalies) were collected, identified, dried, powdered and extracted by using 90% ethanol in soxhlet apparatus. Twenty healthy albino mature male rat’s Rattus norvegicus were used in this study were divided to four groups, including group1 (control group) group 2 were given over-dose of paracetamol for 3 weeks, group 3 were given combination consist from high dose of paracetamol and alcoholic extract of (Rosemary officinalies) for 6 weeks, and group 4 were given rosemary extract for 3 weeks after it was given over-dose of paracetamol for 3 weeks. The histopathological result showed that the alcoholic extract of rosemary officinalis have the protection effect when used in combination with high dose of paracetamol that clear in microscopic appearance of the heart muscle in group 3, while the histopathological result of group 4 revealed the therapeutic effect to the alcoholic extract of rosemary officinalis and the microscopic appearance showed the intact heart muscle. The present study revealed the productive and treated role to alcoholic extract of rosemary officinalis on heart muscle after long term of overdose of paracetamol that showed degeneration and vacuolation in muscle fiber addition that infiltration of inflammatory cell, the extract of this plant resolve the pad tissue changes on the heart tissue especially in group 4 that appear intact heart muscle and in group 3 showed reduce the sign of the overdose. | ||
| Keywords | ||
| paracetamol; Rosmarinus officinalis; Cardio toxicity; Rat | ||
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