Histological changes in the Lacrimal gland of Rabbits after exposure to Formalin and treatment by Ciprofloxacin

Naeem Kareem, Muayad; Hussain .Al-aameli, Muna; Abd-Alsalam Alsalame, Heba

	Histological changes in the Lacrimal gland of Rabbits after exposure to Formalin and treatment by Ciprofloxacin
karbala journal of pharmaceutical sciences
Article 12, Volume 9, Issue 14, 2018, Pages 93-103 PDF (0 K)
Authors
Muayad Naeem Kareem; Muna Hussain .Al-aameli; Heba Abd-Alsalam Alsalame
Abstract
The present study was designed to describe the histological changes in the lacrimal gland of adult rabbits after exposure to formalin and treated by ciprofloxacin. Lacrimal gland samples of fifteen rabbits were collected and divided into three groups, group (I) included (5) rabbits represented control group, while the rabbits in groups (II) included (5) rabbits exposed to formalin, were given two drops were instilled in the one eye/ day of formalin 10% for (7) days. Group (III) which included (5) rabbits were given two drops / day of formalin 10 % were instilled in the one eye for (7) days and in eighth day were treated with eye drops of 0.3% ciprofloxacin. The ciprofloxacin eye drops were instilled in the one eye of each rabbit for (5) days. The samples were fixed in 10 % formalin, routine histological technique was done and stained with Hematoxylin and Eosin ( H& E). The present study revealed as a result of exposure to formalin, there were hypertrophy and hyperplasia in the acinar epithelial cells, increase in the secretory activity of acinar cells, destroyed in some acini also was seen, marked dilation and congestion in the blood vessels and clear dilation in the interlobular ducts. after treatment by ciprofloxacin in group (III), the histological observation of lacrimal gland was similar to that in (I) group.
Keywords
lacrimal gland; Rabbits; Formalin; Ciprofloxacin

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