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Study the effect of oxazepine derivatives of alkaline phosphatase in normal persons sera | ||
| journal of the college of basic education | ||
| Article 1, Volume 12, Issue 58, 2009, Pages 1-8 | ||
| Authors | ||
| Azhar Abbas Ismael Al; | ||
| Abstract | ||
| The inhibitory effect of new organic compound which is derivative of oxazepine on the activity of alkaline phosphatase in normal persons serum have been studied This compound was : 2 ( p-toyl) 3 – (2- traizole ) -2,3 dihydro {1,3} – oxazepine – 4,7 dione The percentage of inhibition caused by oxazepine derivative was to be arranged between 22.5 – 69 % The result from line weaver – burk plot indicated that the inhibition was competitive which maximum velocity vmaxwhile Micheal menten constant Km is decreased in presence of inhibitor 9 m mol/L while the value of Km without inhibitor is 10 m mol/L . synthesis new 1,3 oxazepine 4-7 dion derivatives which are expected to have biological activity which are most active anticonvulsant. | ||
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