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Chromosomal abnormalities associated withmale infertility in Baghdad Iraq | ||
| Jornal of Biotechnology Research Center | ||
| Article 1, Volume 12, Issue 1, 2018, Pages 7-13 | ||
| Authors | ||
| Saad Mohamed Nada; Hazim I. AL-Ahmed; | ||
| Abstract | ||
| In the current study, 142 patients (109 azoospermia and 33 severoligospermia) were studied in order to explore the cytogenetic cause’s background and the hormonal study of male infertility in Baghdad Strip of Iraq. Of the 142 infertile males,14 patients showed abnormal chromosomal karyotypes corresponding to a frequency of 9.85% (14/142), the occurrence of chromosomal abnormalities was only confined to the azoospermia patient group. Patients with abnormal karyotypes represented 12.84% (14/109) of the azoospermia patients. Nine had a 47, XXY karyotype ofKlinefelter's syndrome [47XY;64.28% (9/14)], [47XY+mar;14.28% (2/14)], [46XY,del13(p12) and (del21(p12);7.14% (1/14)], [46XY,tra(5;12, -6); 7.14% (1/14)] and one with chromosomal instability that showed multiple mosaic karyotypes 7.14% (1/14). The hormonal levels of nine patients with Klinefelter's syndrome (KFS) were diagnosed in the present study, and the results showed elevated FSH and LH concentrations compared with control. Whileserum testosterone values were below the control. | ||
| Keywords | ||
| male infertility; cytogenetic; abnormal chromosom | ||
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