- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
Role of Caspase -3 and Total Antioxidant Capacity (TAC) in Idiopathic Infertile Male | ||
| Diyala Journal of Medicine | ||
| Article 1, Volume 14, Issue 2, 2018, Pages 75-85 | ||
| Authors | ||
| Madha Mohammed Sheet Saleh; Estabraq Abdulrasool Al -Wasiti; Adnan Nafil Muslim | ||
| Abstract | ||
| Sperm differentiation during spermatogenesis is highly regulated by different caspases and oxidant-antioxidant mechanisms. Objective: To assess the levels of the caspase -3 and total antioxidant capacity (TAC) in seminal plasma and evaluate its role in the pathogenesis of idiopathic infertile male in comparison with healthy individuals. Patients and Methods: Seminal fluids were collected from seventy males with idiopathic infertility and twenty male with proven fertility and were analyzed for the level of caspase -3 and TAC in seminal fluid and their correlation with seminal fluid quality parameters. Results: The results revealed that men with idiopathic infertility have significantly higher level of caspase-3 activity. Seminal TAC levels were significantly lower in those with idiopathic infertility compared with fertile men. A negative correlation was noticed between sperm quality parameters and TAC levels in idiopathic infertile men. Conclusion: Increased apoptotic index and decreased TAC activity are two important markers in idiopathic male infertility. | ||
| Keywords | ||
| caspase; idiopathic male infertility; Total antioxidant capacity | ||
|
Statistics Article View: 83 PDF Download: 47 |
||