Immunohistochemical Expression of Antioxidant Enzyme PRDX6 in Oral Squamous Cell Carcinoma In Relation to Clinicopathological Parameters

Gheni Taher, Mustafa; Hamdi Younis, Wasan; Muna Salih Merza, And

	Immunohistochemical Expression of Antioxidant Enzyme PRDX6 in Oral Squamous Cell Carcinoma In Relation to Clinicopathological Parameters
Diyala Journal of Medicine
Article 1, Volume 14, Issue 2, 2018, Pages 93-109
Authors
Mustafa Gheni Taher; Wasan Hamdi Younis; and Muna Salih Merza
Abstract
Background:The PRDX6 antioxidant family is important in the protection of cells against oxidants in humans. It is encoded by the PRDX6 gene. Peroxiredoxin 6 antioxidant enzyme (PRDX 6) has been reported in several cancers. However, the function of PRDX 6 in oral squamous cell carcinoma (OSCC),is far from being understood. Objective:To normal corresponding oral mucosa in relation to clinicopathological parameters. Patients and Methods: This study included 40 formalin-fixed, paraffin-embedded tissue blocks of primary OSCC cases and fifteen normal oral mucosa samples. Demographic data, clinical staging and histopathological grading were obtained. Immunohistochemically staining anti PRDX 6 antibody was done to illustrate its subcellular localization in normal and malignant cells. Results: Females were affected more than males and the tongue was the most common site involved. PRDX 6 expression was high in OSCC than normal (p=0.001) with mean±Sd (60±18.8) (23±9.8). Significant correlations were found with tumor size, lymph node and tumor stage (p=0.008, p=0.012, p=0.011 respectively) . Whereas no relation was observed concerning age, gender and tumor site. Conclusion: Significant correlation of PRXD 6 anti oxidant enzyme expression with tumor size, lymph node involvement and clinical staging, suggesting its role in oral squamous cell carcinoma progression.
Keywords
oxidative stress; PRDC; squamous cell carcinoma

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