Effect of Vitamin D3 Supplement on Biochemical Markers and Blood Pressure Reading in Hypertensive patients as A secondary Prevention

Raad Abdulaali, Ameer; Khalid Abdulridha, Manal; Sameh Arif, Inam; Hussein Al-Turfi, Hameed

	Effect of Vitamin D3 Supplement on Biochemical Markers and Blood Pressure Reading in Hypertensive patients as A secondary Prevention
Al-Mustansiriyah Journal for Pharmaceutical Sciences
Article 1, Volume 18, Issue 2, 2018, Pages 24-32
Authors
Ameer Raad Abdulaali; Manal Khalid Abdulridha; Inam Sameh Arif; Hameed Hussein Al-Turfi
Abstract
Hypertension is the most significant risk factors for cardiovascular morbidity and mortality. It has two classes according to causes of the high blood pressure (Primary and Secondary). This study was intended to evaluate the potential benefit of vitamin D3 supplementation as a secondary preventive therapy for hypertensive patients. It is a prospective randomized controlled study was carried out on 40 patients visiting the Imam Al-Hussein medical city / Karbala and conducted from Sep 2016 to May 2017. The patients were allocated into group1; include 20 hypertensive patients presented with vitamin D deficiency assigned to receive conventional therapy for hypertension with vitamin D3 (100000 IU) orally every 2 weeks for 8 weeks, and group 2; include 20 hypertensive patients presented with vitamin D deficiency assigned to receive anti hypertension therapy only. Ethical committee approval and written consent of patients were obtained. Results revealed that the effect of vitamin D3 supplementation on both angiotensin II level and endogenous vitamin D levels were significantly clear regardless of age group, gender, BMI, duration of disease, and smoking status, except for systolic and diastolic blood pressure, TC, and LDL-c was affected particularly by age group and the duration of disease.
Keywords
Hypertension; Vitamin D; Patient demographic characteristics

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