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Evaluation of Interleukin 8, Interleukin 2 Receptor and Serum Ferritin in 60 Patients with BetaThalassemia Major: Relationship to Splenectomy | ||
| Iraqi Postgraduate Medical Journal | ||
| Article 1, Volume 17, Issue 1, 2018, Pages 6-11 PDF (0 K) | ||
| Authors | ||
| Subuh Salim AL-Mudalal; Basma Dawood Hanoon | ||
| Abstract | ||
| ABSTRACT: BACKGROUND: β-Thalassemia is an inhereted hemoglobin disorder characterized by the absence or reduced synthesis of the β-globin chain. Several immunological defects can be found in patients with β-thalassaemia. Increased IL-8 level was documented in patients with β-thalassaemia and it is probably due to overstimulation of macrophages. OBJECTIVE: Evaluation of serum levels of IL-8, soluble IL-2 Receptor, and serum ferritin in the splenectomized and the non-splenectomized β-thalassemia major patients. METHODS: A cross sectional study was conducted on 60 patients with homozygous β-thalassemia major who were attending Al Karama Teaching hospital from May 2011 to Auguest 2011. Place of work was Al-Kadhmia and Al Karama teaching hospital. Patients were divided into two groups; thirty splenectomized, thirty non-splenectomized, and thirty healthy age and sex matched as control group. RESULT: The mean level of IL-8 was increased in both groups of thalassaemia with significantly higher in the splenectomized 333.06±255.50 pg/ml compare to the non-splenectomized 118.61±46.59 pg/ml and the control 38.39±9.52 pg/ml , P-value<0.05. The mean level of sIL-2R was not increased above the reference range in the control subjects, the non-splenectomized and the splenectomized, which was 732.96+28.96 pg/ml, 723.42±74.15pg/ml and 777.38±86.93pg/ml respectively .The mean serum ferritin level in the splenectomized was 2050.1 ng/ml which was significantly higher compared to the non- splenectomized 1212.2 ng/ml, P-value<0.05. There was significant correlation between IL-8 and serum ferritin, P-value<0.05 while there was no significant correlation between s IL-2R and serum ferritin, in both groups of Thalassaemia P value> 0.05. CONCLUSION: - β-thalassemia major patients had increased level of IL- 8 which was more prominent in splenectomized patients, while no increase in IL-2R levels in both groups of Thalassemia. -IL-8 levels correlated with ferritin levels, while no significant correlation between IL-2R levels and ferritin levels in both groups of Thalassaemia. - Splenectomized thalassaemic patients display higher ferritin levels compared to the non-splenectomized. . | ||
| Keywords | ||
| KEY WORDS; ferritin; thalassemia; Splenectomy | ||
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