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Assay of Orphenadrine Citrate in Pharmaceuticals via Extraction-Spectrophotometric Method | ||
| Iraqi Journal of Science | ||
| Article 1, Volume 59, Issue 3, 2018, Pages 1152-1161 | ||
| Authors | ||
| Lazeeza Sattar Omer; Rasul Jameel Ali | ||
| Abstract | ||
| An extraction-spectrophotometric technique has been applied and approved for the estimation of orphenadrine citrate in the presence of paracetamol in a binary synthetic mixture and in combined drugs. The procedure is built on the formation of a soluble red colour orphenadrine citrate – eriochrom black T (EBT) ion pair complex at pH 1.40, while the paractamol not paired. The produced red colour ion-pair complex was extracted with chloroform and showed maximum absorption at 509 nm. For quantitative evaluation Beer’s law applied to plot the absorbance against concentration, the relation was a linear in the concentration range of 0.10-6.00 µg/ mL with the molar absorptivity 4.4025 x104 L / mol. cm. The limit of detection and limit quantification were 0.024 µg/ mL, and 0.100 µg/ mL respectively. The intra-assay precision evaluated in terms of % relative standard deviation (RSD) (< 2%). And accuracy was validated with % recovery (98.8-102.5%). The results showed that orphenadrine citrate could be determined successfully in the combined tablet without interference by paracetamol and other common co-formulated substance. | ||
| Keywords | ||
| Orphinadrine citrate; paracetamol; Ion; pair complex; and Eriochrome black T | ||
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