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Assessment of Interleukin-8 in Patients with Chronic Lymphocytic Leukemia in Correlation with the Prognostic Factors: β2-microglobulin, LDH and Binet Stage | ||
| Iraqi Postgraduate Medical Journal | ||
| Article 1, Volume 17, Issue 2, 2018, Pages 131-136 PDF (0 K) | ||
| Authors | ||
| Haithem Ahmed AL-Rubaie; Safaa Jasim Mohammed | ||
| Abstract | ||
| ABSTRACT: BACKGROUND: Chronic lymphocytic leukemia is a malignancy of mature B cells characterized by progressive lymphocytosis, lymphadenopathy, splenomegaly, and cytopenia. The progressive accumulation of leukemic cells is a consequence of defective apoptosis and survival signals derived from the microenvironment. OBJECTIVE: Is to assess the levels of interleukin-8, 2-microglobulin and lactate dehydrogenase in chronic lymphocytic leukemia patients and evaluate the prognostic value of interleukin-8 in correlation with 2-microglobulin, lactate dehydrogenase and Binet stage. PATIENTS AND METHODS: A case-control study enrolled 40 newly diagnosed chronic lymphocytic leukemia patients attended at Oncology Teaching Hospital, Medical City with 40 adult healthy volunteers as a control group. Interleukin-8, 2-microglobulin and lactate dehydrogenase were investigated. RESULTS: There were statistically significant relationships between Binet staging and each of following: plasma level of interleukin-8, serum level of 2-microglobulin and lactate dehydrogenase and (P= 0.005, 0.005 and 0.023, respectively). There were significant correlations between 2-microglobulin and both interleukin-8 and lactate dehydrogenase level (P= 0.005, both) but correlation between interleukin-8 and lactate dehydrogenase was insignificant. CONCLUSION: Interleukin-8 level was positively correlated with 2-microglobulin, and higher plasma levels were associated with advancing Binet stage which makes it a reliable marker for patients at late clinical stage. | ||
| Keywords | ||
| KEYWORDS; Interleukin; microglobulin; lactate dehydrogenase | ||
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