9.EVALUATION OF PHOSPHO-AKT IMMUNOHISTOCHEMICAL EXPRESSION IN PATIENTS WITH LARYNGEAL SQUAMOUS CELL CARCINOMA

S. Wanas, Nisreen; Y. Mehdi, Luma; K.A. Alzubaidi, Liqa

	9.EVALUATION OF PHOSPHO-AKT IMMUNOHISTOCHEMICAL EXPRESSION IN PATIENTS WITH LARYNGEAL SQUAMOUS CELL CARCINOMA
IRAQI JOURNAL OF MEDICAL SCIENCES
Article 1, Volume 16, Issue 2, 2018, Pages 177-181
Authors
Nisreen S. Wanas; Luma Y. Mehdi; Liqa K.A. Alzubaidi
Abstract
Background: Akt, is a serine/threonine protein kinase which act as an important regulator of cell proliferation and survival. The Akt complex is upregulated by phosphorylation producing phospho-Akt, which trigger a continued cell proliferation and survival and inhibit apoptosis, thereby promote cell survival. Objective: To evaluate the immunohistochemical expression of phosphorylated Akt (Phospho-Akt) in laryngeal squamous cell carcinoma (SCC) and to be correlated with different clinicopathological parameters. Methods: Phospho-Akt expression was investigated Immunohistochemically in 49 formalin-fixed paraffin embedded laryngeal SCC tissue sections collected from Teaching laboratories - Baghdad Medical City. Results: Phospho-Akt positive immunostaining appears in 57% of samples. Akt activation present in advanced stages of tumors with p value 0.02. Conclusion: The current findings may provide evidence that aberrant expression of Akt contributes to the pathogenesis (mechanism of disease development) of laryngeal SCC. Keywords: Akt, phospho-Akt, immunohistochemistry, laryngeal SCC, larynx Citation: Wanas NS, Mehdi LY, Alzubaidi LKA. Evaluation of phospho-AKt immunohistochemical expression in patients with laryngeal squamous cell carcinoma. Iraqi JMS. 2018; 16(2): 177-181. doi: 10.22578/IJMS.16.2.9
Keywords
Akt; phospho; Immunohistochemistry; laryngeal SCC; larynx

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