Influence of platelet rich fibrin on osteointegration of titanium implants stabilized with two different microgaps

Abdulqadir, Mardin Othman; AL- Belasy, Fouad A.; Ali, Youssry Mahmoud; Sobhy Salim, Ahmed

	Influence of platelet rich fibrin on osteointegration of titanium implants stabilized with two different microgaps
Sulaimani Dental Journal
Article 21, Volume 4, Special Issue, 2017, Pages 21-21 PDF (171.15 K)
Authors
Mardin Othman Abdulqadir; Fouad A. AL- Belasy; Youssry Mahmoud Ali; Ahmed Sobhy Salim
Abstract
Aims: This study was aimed to test the influence of platelet rich fibrin on osseointegration of titanium implants initially stabilized in osteotomy sites with 2 different microgaps. Materials and methods: Three male adult dogs with a mean weight of 10 kg and 12 pure titanium implant fixtures (3.3 mm in diameter and 8 mm in length) were used. In each animal, the right and left tibiae were destined to receive 2 implants fixtures, one proximally and one distally spaced at 5 mm apart. Osteotomy sites were created using dental implant drills. The upper 5mm of the proximal osteotomy sites were widened by the next caliber drill (3.75 mm in diameter) to create peri-implant defect size of 0.45 × 5.0 mm (width ×length) in the right tibiae, and by the next caliber drill (4.5 mm in diameter) to create peri-implant defect size of 1.2 × 5.0 mm (width × length) in the left tibiae. Before fixture installation, each proximal osteotomy site was filled with the prepared PRF, and then fixtures installations were done to achieve initial stability. The distal osteotomy sites were drilled in the same manner as the proximal ones but fixtures installations were done without prior placement of PRF. Both scanning electron microscope (SEM) and light microscope were used for microstructural evaluation. Result: SEM examination of bone implant interface without using PRF revealed that most of the area of the pure titanium implant surface was not in direct contact with the newly formed calcified bone matrix and bone trabeculae, while with the use of PRF most of the area of the pure titanium implant surface was in direct contact with the newly formed calcified bone matrix and mature bone trabeculae. Light microscopic examination illustrated close adaptation of bone tissues to the pure titanium implant surface with the use of PRF. However, without the use of PRF there was a gap (space) between implant and bone tissues filled by collagen fibers, calcified bone matrix and little mature and irregular bone trabeculae formation.

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