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Immunohistochemical expression of P-cadherin and cortactin in oral squamous cell carcinomas | ||
| Sulaimani Dental Journal | ||
| Article 2, Volume 2, Issue 1, 2015, Pages 8-16 PDF (1.92 M) | ||
| DOI: 10.17656/sdj.10030 | ||
| Authors | ||
| Dena N. Mohammad1; Balkees T. Garib1; Hassanain H. Khudeir2; Ban A Abdul–Majeed1 | ||
| 1College of Dentistry, University of Sulaimani | ||
| 2College of Medicine, University of Baghdad | ||
| Abstract | ||
| Objectives: to assess the expression and pattern distribution of P-cadherin and cortactin in OSCC, and to relate such expression to the histopathological grading. Materials and Methods: An immunohistochemical staining for P-cadherin and cortactin was performed on paraffin blocks of 40 oral squamous cell carcinoma and five normal mucosa. Fisher's exact test and Spearman's rank-order correlation were applied for analysis. P < 0.05 was considered statistically significant. Results: P-cadherin was either aberrantly cytoplasmic re-localized or lost in 45% of cases. 58.6% of positive cases were in grade I. Focal heterogeneous pattern was the commonest pattern (27.5%) and related to the degree of cell differentiation. The expression percentage was reported mainly in score 1 and 2 with no differences among histopathological grades (P=0.778). On the other hand, 70% of oral SCC had cytoplasmic cortactin expression. The majority of cases (85.7%) expressed diffuse pattern including all positive grade II and III cases. Nevertheless, statistical analysis did not reach a significant level (P= 0.722). Furthermore, no significant correlation was found between P-cadherin and cortactin expression. Conclusion: Oral SCC had P-cadherin under-expression (focal) and cortactin over-expression (diffuse). The P-cadherin pattern distribution rather than expression percentage was related to the degree of cell differentiation. The expressions of these molecules were unrelated to each other. | ||
| Keywords | ||
| oral squamous cell carcinoma; P-cadherin; cortactin | ||
| References | ||
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